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Ana Slipicevic Selected Research

melflufen

3/2022The Peptide-Drug Conjugate Melflufen Modulates the Unfolded Protein Response of Multiple Myeloma and Amyloidogenic Plasma Cells and Induces Cell Death.
1/2022Growth Response and Differentiation of Bone Marrow-Derived Mesenchymal Stem/Stromal Cells in the Presence of Novel Multiple Myeloma Drug Melflufen.
12/2021Melphalan flufenamide inhibits osteoclastogenesis by suppressing proliferation of monocytes.
7/2021Novel Peptide-drug Conjugate Melflufen Efficiently Eradicates Bortezomib-resistant Multiple Myeloma Cells Including Tumor-initiating Myeloma Progenitor Cells.
3/2021Aminopeptidase Expression in Multiple Myeloma Associates with Disease Progression and Sensitivity to Melflufen.
1/2020Targeting aggressive osteosarcoma with a peptidase-enhanced cytotoxic melphalan flufenamide.
1/2020Melflufen, a peptide-conjugated alkylator, is an efficient anti-neo-plastic drug in breast cancer cell lines.

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Ana Slipicevic Research Topics

Disease

18Neoplasms (Cancer)
03/2024 - 01/2008
15Melanoma (Melanoma, Malignant)
01/2021 - 04/2005
7Multiple Myeloma
03/2022 - 01/2020
4Carcinoma (Carcinomatosis)
01/2016 - 01/2008
4Nevus (Nevi)
02/2012 - 10/2005
3Neoplasm Metastasis (Metastasis)
01/2020 - 01/2008
3Breast Neoplasms (Breast Cancer)
01/2020 - 04/2009
2Disease Progression
03/2021 - 01/2014
2Vulvar Neoplasms (Vulvar Cancer)
01/2018 - 01/2015
1Ataxia Telangiectasia (Louis Bar Syndrome)
03/2024
1Rare Diseases (Rare Disease)
03/2022
1Immunoglobulin Light-chain Amyloidosis
03/2022
1Bone Resorption
12/2021
1Necrosis
01/2020
1Osteosarcoma (Osteogenic Sarcoma)
01/2020
1Prostatic Neoplasms (Prostate Cancer)
11/2017
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
01/2015
1Mesothelioma
04/2009
1Malignant Mesothelioma
04/2009
1Neuroendocrine Tumors (Neuroendocrine Tumor)
11/2006

Drug/Important Bio-Agent (IBA)

8Proteins (Proteins, Gene)FDA Link
03/2024 - 04/2005
7melflufenIBA
03/2022 - 01/2020
4Peptides (Polypeptides)IBA
03/2022 - 01/2020
4Biomarkers (Surrogate Marker)IBA
01/2016 - 01/2010
4ParaffinIBA
02/2012 - 11/2006
3EnzymesIBA
03/2024 - 04/2009
3AminopeptidasesIBA
03/2022 - 01/2020
3Small Interfering RNA (siRNA)IBA
01/2018 - 02/2012
3Cyclin AIBA
02/2012 - 10/2005
2Methylenetetrahydrofolate Dehydrogenase (NADP) (Dehydrogenase, Methylenetetrahydrofolate)IBA
03/2024 - 01/2023
2CarbonIBA
03/2024 - 01/2023
2ChromatinIBA
03/2024 - 03/2015
2Alkylating AgentsIBA
03/2022 - 01/2020
2Doxorubicin (Adriamycin)FDA LinkGeneric
01/2020 - 01/2020
2Cyclin D3IBA
02/2012 - 01/2012
2Fatty Acid-Binding Protein 7IBA
02/2012 - 09/2008
2Insulin-Like PeptidesIBA
01/2010 - 04/2009
2Formaldehyde (Formol)FDA Link
11/2008 - 11/2006
2Messenger RNA (mRNA)IBA
09/2008 - 01/2008
2TensinsIBA
01/2008 - 10/2005
1DNA (Deoxyribonucleic Acid)IBA
03/2024
1DNA-Activated Protein KinaseIBA
03/2024
1formic acid (formate)IBA
01/2023
1Folic Acid (Vitamin M)FDA LinkGeneric
01/2023
1Oxidoreductases (Dehydrogenase)IBA
01/2023
1NucleotidesIBA
01/2023
1Immunoglobulin Light Chains (Immunoglobulin Light Chain)IBA
03/2022
1Amyloid (Amyloid Fibrils)IBA
03/2022
1Melphalan (Alkeran)FDA LinkGeneric
12/2021
1Bortezomib (Velcade)FDA Link
07/2021
1Proteasome InhibitorsIBA
07/2021
1Immunoglobulins (Immunoglobulin)IBA
03/2021
1InterferonsIBA
01/2021
1VemurafenibIBA
01/2021
1carfilzomibIBA
01/2021
1trametinibIBA
01/2021
1Peptide Hydrolases (Proteases)FDA Link
01/2020
1RNA (Ribonucleic Acid)IBA
01/2020
1PlasticsIBA
01/2020
1alvocidib (flavopiridol)IBA
11/2017
1Cyclin-Dependent Kinases (cdk Proteins)IBA
11/2017
1MicroRNAs (MicroRNA)IBA
01/2016
1adavosertibIBA
06/2015
13- (carbamoylamino)- 5- (3- fluorophenyl)- N- (3- piperidyl)thiophene- 2- carboxamideIBA
06/2015
1Protein Phosphatase 2 (Protein Phosphatase 2A)IBA
06/2015
1GalactosidasesIBA
03/2015
1Cyclin B1IBA
01/2015
1Monoclonal AntibodiesIBA
02/2013
1TNF-Related Apoptosis-Inducing Ligand ReceptorsIBA
02/2013
1AnisomycinIBA
02/2013
1lexatumumabIBA
02/2013
1Sepharose (Agarose)IBA
01/2012
1Insulin-Like Growth Factor Binding Protein 3IBA
01/2010
1Insulin-Like Growth Factor II (Somatomedin A)IBA
04/2009
1ImmunosorbentsIBA
04/2009
12- (2- amino- 3- methoxyphenyl)- 4H- 1- benzopyran- 4- oneIBA
09/2008
1RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
01/2008
1PTEN Phosphohydrolase (PTEN Phosphatase)IBA
01/2008
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
10/2005
1Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
10/2005
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
04/2005
1lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)IBA
04/2005
1Phorbol EstersIBA
04/2005
1SuspensionsIBA
04/2005
1Antisense OligonucleotidesIBA
04/2005

Therapy/Procedure

6Therapeutics
03/2024 - 01/2012
2Drug Therapy (Chemotherapy)
06/2015 - 10/2014